Endocrine Abstracts

Introduction-Cushing's syndrome is characterised by hypercortisolaemia, loss of the diurnal rhythm of cortisol secretion and loss of negative hypothalamic-pituitary-adrenal (HPA) feedback. Patients with adrenal incidentalomas may manifest some signs of cortisol excess before developing overt Cushing's syndrome. This can be considered as 'Cushing's syndrome in evolution'.Case History-A 47 year old lady with ty...

Thyroid eye disease usually occurs in patients with graves'hyperthyroidism although 5-10% of patients are euthyroid or are hypothyroid with positve TSH receptor binding antibodies. We describe a patient with primary hypothyroidism for 14 years prior to the onset of severe thyroid eye disease.A 61 year old lady with thyroid opthalmopathy was seen in the eye clinic.Previous history included diet controlled diabetes and primary hypothyroidism, adequately r...

Microprolactinomas are the commonest pituitary tumour and respond well to dopamine agonist (DA) therapy with resolution of symptoms and tumour shrinkage occurring in the vast majority of cases. Reports also suggest that up to 20% of cases may achieve long-term normoprolactinaemic remission following withdrawal of chronic dopamine agonist therapy yet interruption of therapy is not universally practised nor is there consensus on the duration of therapy. In this retrospective stu...